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Evidence is increasing that most addiction without exception is related to difficulties with the brain's reward center, specially the mesolimbic system. This area of the problem regulates reward responses in getting food and sex, plus nurturing infants and children. One of the most important neurotransmitters linked to reward responses, both when they malfunction and once they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the amount of dopamine released in in response to a stimulus"(Bostwick & Bucci, 2008).

Using two separate drugs to lose weight naturally can be very effective you will find combinations as you're watching FDA now awaiting approval. When dealing with fat loss and the individuals who go through it you should err on the side of caution and let the FDA do its job and demand some research be done so your public understands the side effects and dangers of the medications before we bring them. Keep in mind that drug companies will be in business to earn money and that they would say anything to keep people on his or her medications.

Researchers found that participants taking this drug to get a year, dropped excess weight within 4 weeks and have kept the weight off through the entire 56 weeks with the study. Contrave can be a combination in the drugs naltrexone and bupropion, which usually reflect a whole new trend of weight-loss drugs that are made up of several active ingredient, which might make them more effective and safer.

Combo-pilling is the newest fad or better yet the newest into the future under scrutiny and for that reason it is just more publicly known although in the past, comb-pilling for weight loss has been around since the eighties. The biggest reason that employing a combination of pills has become popular is the fact that by right now there are not any long term prescription slimming capsules that have been authorized by the FDA besides orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications even though some of the combinations happen to be rejected or have yet to be authorized by the FDA.

Seizures can be a side effect with Contrave and really should not be taken in people with seizure disorders. The drug could also raise blood pressure levels and heart rate, and shouldn't be used in people with a history of cardiac event or stroke in the last six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy using the drug.

The FDA also warned that Contrave can raise hypertension and heartbeat and must not be used in patients with uncontrolled high blood pressure, along with by a person with heart-related and cerebrovascular (circulatory dysfunction impacting mental performance) disease. Patients with a history of cardiac event or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes having a boxed warning to alert medical researchers and patients towards the increased probability of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for quitting smoking.

The most common side effects with Contrave include nausea, constipation, headache, vomiting, dizziness, insomnia, dry mouth, and diarrhea.